Intellectual Developmental Disabilities Research Center

2018 IDDRC Projects and Supporting Cores


Grant Number and Title Clinical Translational Core Genetics Core Translational Neuroscience Core Neuroimaging Core Behavior Science Core
Aggarwal R21NS096249-01A1: Oscillating Gradient Diffusion MRI and Quantitative Susceptibility Mapping in the Epileptogenic Brain X
Atkinson UL1-TR001079 (NBRU): Chronic Kidney Disease in Chldren Study (CkiD) X
Bastian R01 HD040289: Mechanisms and Rehabilitation of Cerebellar Ataxia X
Baumgartner R01 HL091541: Excitotoxicity in circulatory arrest-brain injury X
Bembea K23 NS076674: Novel methods of Brain Injury Detection and Outcome Prediction in Pediatric ECMO X
Bjornsson DP5 OD017877: Clinical Confirmation of Novel Computational Genetic Elements X
Bjornsson DP5 OD017877: Exploring Kabuki Syndrome as a treatable cause of intellectual disaiblity X
Blue/Kannan R21 NS100085: Dendrimer Therapies for Treatment of Rett Syndrome X X
Brasic JHUSM BriteStar Award: The Feasibility Study of Metabotropic Glutamate Receptor Type 5 Function in Fragile X Syndrome X
Budimirovic Ovid Therapeutics, Inc.: A Phase 2a, Randomized, Double-Blind, Parallel-Group, Proof-of-Concept Study Evaluating the Safety, Tolerability, and Efficacy of OV101 in Fragile X Syndrome X
Burd K08 HD073315: IL-1β Regulation of Perinatal Brain Injury X X
Capone UL1-TR001079 (NBRU): Depression and Sleep Disorders in Adolescents and Young Adults with Down syndrome X
Carnell UL1-TR001079 (NBRU): Neurobehavioral Influences on Body Weight X
Cayton Vaught Edward E. Wallach Research Fellowship Grant and UM1 HG006542: Demystifying Unexplained Recurrent Pregnancy Loss Through Next Generation Sequencing Technologies X
Celnik R01 HD053793: Novel Strategies to enhance motor function after stroke X
Celnik R01 HD073147: Understanding motor behavior after stroke X
Cheng K01 AA020873: Neuroimaging of Eyeblink Conditioning in Subjects with Alcohol Use Disorders X
Comi Faneca 66 Foundation: Cannabidiol expanded access study in medically refractory Sturge-Weber syndrome X
Comi Faneca 66 Foundation: Trial of sirolimus for cognitive impairments in Sturge-Weber syndrome X
Cutting R01 DK044003: Molecular genetics of cystic fibrosis: Creation and characterization of an airway epithelial cell line for stable expression of exogenous genes X
Edden Brian’s Hope Foundation: Nanodendrimer-Based Targeted Delivery of the N-Acetylcysteine for Adrenoleukodystrophy: A Pilot Study to Determine Feasibility of Clinical Translation X
Edden UL1-TR001079 (NBRU): Dysfunction of Sensory Inhibition in Autism X
Ehsani Hopkins Science of Learning Institute: Neurophysiological Measures of Hazard Perception Among Novice and Teenage Drivers X
Everett R01 HD68446: GFAP Biomarker of Whole Body Cooling Outcome and Efficacy in the Neonate with HIE X X
Ewen R21 NS091569: Direct Examination of Imitation Based Learning in ASD X X X
Fatemi R01 NS097511: Targeted Therapies for Neonatal White Matter Injury X X
Fatemi Brian’s Hope Foundation: Nanodendrimer-Based Targeted Delivery of the N-Acetylcysteine for Adrenoleukodystrophy: A Pilot Study to Determine Feasibility of Clinical Translation X
Fatemi A Cure for Ellie Foundation: Characterization of the Natural History of Leukoencephalopathy with Brainstem and Spinal Cord Involvement and Lactate Elevation X
Findling R01 MH073967: Longitudinal Assessment of Manic Symptoms X X
Findling NCT02674633: Software Treatment for Actively Reducing Severity of ADHD (STARS-ADHD) X
Findling Supernus Pharmaceuticals, SPN810P301: A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Molindone Hydrochloride Extended-Release Tablets for the Treatment of Impulsive Aggression in Pediatric Patients with Attention Deficit/Hyperactivity Disorder (ADHD) in Conjunction with Standard ADHD Treatment Objectives X X
Findling Dasotraline Pediatric Extension Study X
Findling Safety and Tolerability Study of SPD489 in Preschool Children Aged 4-5 Years, Diagnosed With Attention-deficit/Hyperactivity Disorder X
Germain-Lee R21 HD078864: The Role of G Protein-Coupled Signaling in Neurocognitive and Psychosocial Abnormalities X
Hagopian R01 HD076653: Delineating subtypes of self-injurious behavior maintained by automatic reinforcement X
Hardwick R01 NS083373: Mechanisms of Neurodegeneration X
Harris Rubenstein Taybi Syndrome Foundation: Characterizing the Neurocognitive and Neurophysiologic Phenotype of Rubinstein-Taybi Syndrome X X X
Hoover-Fong/Gunay-Aygun 03-HG-0264, NCT00068224: Clinical and Molecular Investigations into Ciliopathies X
Jacobson PCORI Research Institute: Surviving Cancer, Thriving in Life: Health-related Quality of Life after Pediatric Cancer X
Jacobson PCORI Research Institute: Surviving Cancer, Thriving in Life: Health-related Quality of Life after Pediatric Cancer X
Johnson U01 NS038455: Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) X
Johnston 2K12 NS001696: Neurology Sciences Academic Development Award (NSADA) X X
Johnston Kennedy Krieger Institute-Johns Hopkins Medicine Interdisciplinary Cerebral Palsy (CP) Center of Research Excellence (KKI-JHM CPCRE): Nanomedicine-Based Therapy for Perinatal White Matter Injury X X X
Kadam R01 HD090884: Mechanisms Regulating KCC2 Hypofunction During Refractory Seizures in a Mouse Model of Ischemic Neonatal Seizures X
Kamiya/Pletnikov R01 DA041208: Molecular Mechanism of Astrocytic Vulnerability to Adolescent Cannabis Use      X
Kannan R01 HD069562: Mechanisms and Novel Therapy in Intrauterine Inflammation Induced Brain Injury X
Kannan R01 NS093416: Targeting Glutamate Carboxypeptidase in Perinatal Brain Injury X X
Keefer Private Donor: A Pilot Investigation of a Novel Child/Parent Mindfulness Intervention to Improve Emotional Dysregulation in Children with Autism Spectrum Disorders X
Krinsky-McHale/Silverman P01 HD035897: Aging and Dementia in Adults with Down syndrome.  Subproject 2: (8402) Validation of Criteria for Identifying “MCI” in Adults with Down syndrome. X X
Lance 1K23HL133455: Neuroimaging, Protein Biomarkers, and Neurodevelopment in Very Young Children with Sickle Cell Disease X X X
Landa R01 MH059630: Autism social and communication predictors in siblings X
Laterra R01 NS076759: Suppression of Glioblastoma Stem Cells by Kruppel-Like Factor 9 X
Laterra R01 NS096754: Chromatin Modifications in GBM-Propagating Cells X X
Lee R01 NS093213: Cell extrinsic factors’ roles on direct conversion to human induced neural crest X
Li R35 GM118172: Cellular Dynamics in Division, Motility, and Evolutionary Adaptation X
Lin UL1-TR001079 (NBRU): Noninvasive imaging and functional correlation of intracranial pial angiomatosis (SWS) X
Maegawa R01 NS079655: Development of an HTS assay for a neurological lysosomal disease X
Mahone R01 HD068425: Development of ADHD in Preschool Children: Neuroimaging and Behavioral Correlates X X
Mahone UL1-TR001079 (NBRU): DNA Methylation in Children with ADHD and/or Dyslexia X
Mahone Maryland State Department of Education (MSDE): Improving Equity in Access and Opportunity for Students with Disabilities X
Mahone Maryland State Department of Education (MSDE):  School-Based Uses of Applied Behavior Analysis: Open Online Modules for Teachers, Administrators, and Special Education Student Support Staff X
Mahone Department of Education (DOE): Neuroscience of Learning and the Learner X
Meador U01 NS038455: Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs (MONEAD) X
Miller R01 EB020062:  Neurogenerative and Neurodevelopmental Subcortical Shape Diffeomorphometry X X
Moler U01 HL094345: Therapeutic Hypothermia After Pediatric Cardiac Arrest: A Randomized Controlled Trial (THAPCA) X X
Mostofsky R01 MH078160: 1/2 Anamalous Motor Physiology in ADHD X X
Mostofsky R01 MH085328: Adolescent Changes in Brain and Behavior in Boys and Girls with ADHD of deficient response control in ADHD X X
Mostofsky/Gilbert R01 NS096207: GABAergic Sensorimotor Dysfunction in Tourette Syndrome X X
Naidu R01 FD004247: PH2 Study of dextromethorpan in the treatment of Rett syndrome X X X X
Nebel K01MH109766: Visual-Motor Development in Infants at High Risk for Autism X
Northington R01 HD070996: Mechanisms of hypothermic neuroprotection in neonates X X
Pelled R01 NS072171: The role of transcallosal pathway to neuroplasticity following nerve injury X
Pevsner U01 MH106884: Role of somatic mosaicism in autism, schizophrenia and bipolar disorder brain X
Pevsner UL1-TR001079 (NBRU): DNA in Children with Developmental Disabilities X
Pletnikov R01 MH083728: DISC1 in Neuron-Astrocyte Interactions in Neurodevelopment  X
Pritchard R03 EB023359: Role of Peripheral and Brain Iron in the Development of Attention and Cognitive Control X X
Puts K99 MH107719: A Multimodal Investigation of Inhibitory Dysfunction in Autism Spectrum Disorder X
Reeves R01 HD038384: Genomic Approaches to Aneuploidy X
Reti R21 HD092915: Neuromodulation Treatment for Self-Injurious Behavior Associated with Intellectual and Developmental Disabilities X
Robertson 5U01NS081041-02: Approaches and Decisions in Acute Pediatric TBI (ADAPT) X
Rosch K23 MH101322: Delay Discounting in Children with ADHD: Neuroimaging and Behavioral Correlates X X
Ruble/Jacobson Saint Baldrick’s Foundation: Sleep and Neurocognitive Outcomes in Childhood ALL Survivors X
Sadowsky Ekso Bionics, 105333: Adherence to Home-Based Functional Electrical Stimulation (FES) Exercise in Patients with Spinal Cord Injury (SCI) X X
Salpekar NCT03371836: Use of Clobazam in Treating Anxiety Comorbid with Pediatric Epilepsy X X
Scafidi K08 NS069815: Metabolic dysfunction and neuroprotection after pediatric head injury X
Schupf/Lott/Silverman U01 AG051412: Biomarkers of Alzheimer’s disease in adults with Down syndrome X X X X
Schupf/Silverman P01 HD035897: Aging and Dementia in Adults with Down syndrome. Subproject 4: (8404) Genetic Epidemiology of Alzheimer’s Disease in Down syndrome X
Seymour K23 MH107734:  Neurobehavioral correlates of frustration in ADHD X X
Silverman P01 HD035897: Aging and Dementia in Adults with Down syndrome X
Singer Tourette Association of America (TAA): Home-based Behavioral Intervention for Tics, Comparison of Home-based DVD Therapy and Psychologist-directed CBIT Treatment X
Song Tourette Association of America (TAA): Home-based Behavioral Intervention for Tics, Comparison of Home-based DVD Therapy and Psychologist-directed CBIT Treatment X
Suskauer UL1-TR001079 (NBRU): Neural Basis of Impairments in Response Inhibition and Processing Speed X
Suskauer R01 HD090266: Subtle Motor Functioning and Functional Connectivity in Youth Medically Cleared After Mild TBI X X
Tifft NHGRI Rare Impact Award: Diagnosis and Segregation of Undiagnosed Disease X
Tycko/Silverman P01HD035897: Aging and dementia in adults with Down syndrome. Subproject 3: (8403) Epigenetic Modifiers in Down syndrome X
Valle UM1 HG006542: Baylor-Johns Hopkins Center for Mendelian Genetics X X
Vernon K08HD073492: Metabolic studies in disorders of branch chain amino acid metabolism X X
Wagner U54 HD060848: Biomarkers for Therapy of FSHD X
Wagner NCT01847573: Safety, Tolerability, and Pharmacokinetics of Single and Multiple Doses of HT-100 in Duchenne Muscular Dystrophy X
Wang R21NS085358: DHHC 15 palmitoylation modulates striatal dopamine system X
Watkins R21NS091988: Drug Discovery for X-Linked Adrenoleukodystrophy X X
Watson 5R01 HD074757: Sedation Strategy and Cognitive Outcome After Critical Illness in Early Childhood X
Wilson U54HD079123: IDDRC Research Component (6271): Multi-modal Treatment for Neonatal HIE: Hypothermia and Dendrimer Nanotherapy X X X
Wu R21NS098018: In-Utero Characterization of Embryonic Mouse Brain Development and Injury with MRI X
Xia 5R01NS091165: Effect of IDH1 Mutation on Chromosome Instability X X
Yau R01EY014596: Melanopsin Photoreception and Signaling X
Zhang R01HD074593: Imaging neonatal hypoxic ischemic injury X